Recent Publications
- Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis I, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow F, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG. p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Nature Communications. 2024 Apr 8; 15(1):3018. https://doi.org/10.1038/s41467-024-47124-8
- Hendrickson PG, Oristian KM, Browne MR, Luo L, Ma Y, Cardona DM, Nash JO, Ballester PL, Davidson S, Shlien A, Linardic CM, Kirsch DG. Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene. 2024 Feb 27. doi: 10.1038/s41388-024-02984-8. Epub ahead of print. PMID: 38413794.
- Floyd W, Pierpoint M, Su C, Patel R, Luo L, Deland K, Wisdom AJ, Zhu D, Ma Y, DeWitt SB, Williams NT, Lazarides AL, Somarelli JA, Corcoran DL, Eward WC, Cardona DM, Kirsch DG. Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus. J Clin Invest. 2023 Jul 3;133(13):e149310. doi: 10.1172/JCI149310. PMID: 37200088; PMCID: PMC10313374.
- Lopez OM, Zhang M, Hendrickson PG, Huang J, Daniel AR, Blackmer J, Luo L, Attardi LD, Corcoran D, Kirsch DG. p53 and RB Cooperate to Suppress Transposable Elements. bioRxiv 2023.02.06.527304; doi: https://doi.org/10.1101/2023.02.06.527304
- Wisdom AJ, Mowery YM, Hong CS, Himes JE, Nabet BY, Qin X, Zhang D, Chen L, Fradin H, Patel R, Bassil AM, Muise ES, King DA, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams NT, Luo L, Ma Y, Alizadeh AA, Owzar K, Diehn M, Bradley T, Kirsch DG. Single Cell Analysis Reveals Distinct Immune Landscapes in Transplant and Primary Sarcomas that Determine Response or Resistance to Immunotherapy. Nature Communications. 2020 Dec 17;11(1):6410. doi: 10.1038/s41467-020-19917-0. PMCID: PMC7746723
- Lee CL*, Brock KD, Hasapis S, Zhang D, Sibley AB, Qin X, Gresham J, Caraballo I, Luo L, Daniel AR, Hilton MJ, Owzar K, Kirsch DG*. Whole Exome Sequencing of Radiation-induced Thymic Lymphoma in Mouse Models Identifies Notch 1 Activation as a Driver of p53 wild-type Lymphoma. Cancer Research 2021 May 25; canres.2823.2020.doi: 10.1158/0008.5472.CAN-20-2823. PMCID: PMC8286346. *=co-senior authors
- Chen M, Foster II JP, Lock IC, Leisenring NH, Daniel AR, Floyd W, Xu ES, Davis IJ, Kirsch DG. Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP. Cancer Research 2021 Oct; 81(19):4939-4948. doi:10.1158/0008-5472 PMCID: PMC8487964
- Daniel AR, Lee CL, Su C, Williams NT, Li Z, Huang J, Lopez OM, Luo L, Ma Y, Campos L, Selitsky SR, Modliszewski JL, Liu S, Mowery YM, Cardona DM, Kirsch DG. Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas bioRxiv 2022.10.28.514234; doi: https://doi.org/10.1101/2022.10.28.514234
- Himes JE, Wisdom AJ, Wang L, Shepard SJ, Daniel AR, Williams N, Luo L, Ma Y, Mowery YM, Kirsch DG. Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas. bioRxiv. 2023 Apr 6:2023.04.04.535550. doi: 10.1101/2023.04.04.535550. Preprint. PMID: 37066384