Research programs

We use Cre-loxP technology to delete genes in a cell-type specific manner and apply sophisticated small animal irradiation to study mechanisms of radiation injury and regeneration in the intestine and other tissues.

We study mechanisms of sarcoma development and tumour maintenance in undifferentiated small round cell sarcoma driven by the CIC::DUX4 fusion oncoprotein and in epithelioid sarcoma initiated by loss of SMARCB1, a subunit of the SWI/SNF protein complex.

Using autochthonous sarcoma models, we study mechanisms of tumour response to radiotherapy alone or to a combination of radiation and immunotherapy.

We study mechanisms of tumour suppression by the three genes most frequently mutated in complex karyotype sarcomas: p53, Rb, and ATRX.